National Institutes of Health, a Component of the US Dept. of Health & Human Services

John A Cook

James B Mitchell

Murali Krishna Cherukuri

Sankaran Subramanian

Nallathamby Devasahayam

Angelo Russo

Frank S Harrington

Rolf G Tschudin

Ramachandran Murugesan

Shingo Matsumoto

Mobae Afeworki

An echo-based single point imaging (ESPI) system () providing high-resolution oxygen images of a sample is disclosed. The ESPI system () employs spin echo detection of the resonance from a spin probe and concurrent Single Point Imaging (SPI) for spatial encoding of the oxygen concentration within the sample. Images are derived by comparing spin echo intensities of two images reconstructed at two time points selected at identical time intervals on either side of a refocusing pulse, eliminating artifacts associated with sample magnetic susceptibility and field inhomogeneity effects.

Quantitative oxygen imaging systems and methods using echo-based single point imaging

A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.

Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy

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Bethesda, MD, United States of America

John A Cook