A. Nattermann & Cie Gmbh

Nattermann & Cie Gmbh

Johannes Winkelmann

Hans-Heiner Lautenschlager

Manfred Probst

Eugen Etschenberg

Hans Betzing

Axel Brekle

Sigurd Leyck

Gerrit Prop

Gerd Hilboll

Andre Welter

Jurgen Biedermann

Michael J Parnham

Brigitte Stoll

Hugo Friehe

Ferdinand Wirtz-Peitz

Ottfried Zierenberg

Wolfgang Scheef

Marcel Renson

The invention relates to new .omega.-aryl-alkylthienyl compounds having the Formula I ##STR1## i.e. omega-aryl-alkyl thienyl alkanoic acids and, respectively, omega-aryl-alkyl thienyl alkenoic acids, the alkali metal salts of such acids and certain esters thereof. The invention further relates to processes for the treatment of chronically inflammatory processes in humans.

Omega-aryl-alkylthienyl-compounds and process for the treatment of

The invention relates to the new optically active dipeptide D-2-phenylglycyl-D-2-phenylglycine and its pharmacologically acceptable salts or acid addition salts and the use thereof as tissue dissolving and histolytic agent.

Optically active dipeptides and the use thereof as tissue dissolving and

The invention relates to new triphenylimidazolyloxyalkanoic acids of the general formula I ##STR1## and a process for the treatment of thromboembolic, inflammatory and/or atherosclerotic diseases in humans by using the same.

Triphenylimidazolyloxyalkanoic acids and their derivatives and a process

The present invention is directed to a new rosmarinic acid-phospholipide-complex product containing rosmarinic acid and the phospholipide in a molar ratio of 1:2. The invention is further directed to a process for producing the same and to pharmaceutical preparations containing the same.

Rosmarinic acid-phospholipide-complex

The present invention is related to pharmaceutical preparations containing as active components the known compound 2-phenyl-1.2-benzisoselenazol-3(2H)-one containing pharmaceutical preparations and process for the treatment in particular of rheumatic diseases.

2-Phenyl-1,2-benzisoselenazol-3(2H)-one containing pharmaceutical

The present invention refers to new 5-(N-Alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives having the general formula I ##STR1##

5-(N-Alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives

The invention provides novel .omega.-(5-alkenylthien-2-yl)alkanecarboxylic acids and their functional derivatives having the formula ##STR1## wherein n is an integer from 1 to 9, inclusive; R.sup.1 is H and R.sup.2 is --OH, or R.sup.1 and R.sup.2 together with the wavy lines represent a keto group; and R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched-chain saturated hydrocarbon, or a pharmaceutically acceptable alkali cation. The 3-oxoalkenyl-substituted compounds of formula (I) are prepared by a Wittig-Horner reaction using a 2-oxoheptylphosphonic acid dialkyl ester and an aldehyde of the formula ##STR2## as starting materials, while the 3-hydroxyalkenyl-substituted compounds are obtained by reduction of the corresponding 3-oxoalkenyl compounds. The esters of formula (I) can also be readily converted to the corresponding acids and salts of formula (I). The compounds of the invention have valuable anti-inflammatory, antipyretic and anti-arteriosclerotic properties, yet have low toxicity and do not irritate the gastric mucosa.

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Cologne, Germany

Johannes Winkelmann