Janssen R&d Ireland

Elanco Animal Health Ireland Limited

Johannes Wilhelmus J Thuring

Bart Rudolf Romanie Kesteleyn

Bengt Bertil Samuelsson

Hans Kristian Wallberg

Genadiy Kalayanov

Wim Bert Griet Schepens

Kevin Parkes

Jörg Kurt Wegner

Joerg Kurt Wegner

Compound having formula I and pharmaceutically acceptable salts or solvates thereof, their pharmaceutical formulations and use as HIV inhibitors.

Macrocyclic integrase inhibitors

HIV inhibitors of formula (I) wherein Ris halo, Calkoxy, trifluoromethoxy; Ris a group of formula (A); Ris a group of formula (B); Ris a group of formula (C); n is 0 or 1; A is CH or N; Rand Rare hydrogen, Callyl, halo; Rand Rare Callyl or Calkoxy-Calkyl; Ris Callyl, cyclopropyl, trifluoromethyl, Calkoxy, or dimethylamino; Ris hydrogen, Calkyl, cyclopropyl, trifluoromethyl, Calkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.

5-amino-4-hydroxypentoyl amides

Compound having formula (I), wherein &#x2014;W is NH&#x2014;, &#x2014;N(CH)&#x2014; or piperazine, &#x2014;X is a bond, &#x2014;C(&#x2550;O)&#x2014; or S(&#x2550;O)&#x2014;, &#x2014;Y is Calkylene, and &#x2014;Z is NH&#x2014;C(&#x2550;O)&#x2014; or &#x2014;O&#x2014;, and pharmaceutically acceptable salts thereof, their pharmaceutical formulations and use as HIV inhibitors. 

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Beerse, Belgium

Johannes Wilhelmus J Thuring