Janssen R&d Ireland

Elanco Animal Health Ireland Limited

Johannes Wilhelmus J Thuring

Jean-François Bonfanti

Bart Rudolf Romanie Kesteleyn

Bengt Bertil Samuelsson

Jérôme Michel Claude Fortin

Hans Kristian Wallberg

Genadiy Kalayanov

Wim Bert Griet Schepens

Kevin Parkes

Jörg Kurt Wegner

Joerg Kurt Wegner

Compound having formula I and pharmaceutically acceptable salts or solvates thereof, their pharmaceutical formulations and use as HIV inhibitors.

Macrocyclic integrase inhibitors

HIV inhibitors of formula (I) wherein Ris halo, Calkoxy, trifluoromethoxy; Ris a group of formula (A); Ris a group of formula (B); Ris a group of formula (C); n is 0 or 1; A is CH or N; Rand Rare hydrogen, Callyl, halo; Rand Rare Callyl or Calkoxy-Calkyl; Ris Callyl, cyclopropyl, trifluoromethyl, Calkoxy, or dimethylamino; Ris hydrogen, Calkyl, cyclopropyl, trifluoromethyl, Calkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.

5-amino-4-hydroxypentoyl amides

Compound having formula (I), wherein &#x2014;W is NH&#x2014;, &#x2014;N(CH)&#x2014; or piperazine, &#x2014;X is a bond, &#x2014;C(&#x2550;O)&#x2014; or S(&#x2550;O)&#x2014;, &#x2014;Y is Calkylene, and &#x2014;Z is NH&#x2014;C(&#x2550;O)&#x2014; or &#x2014;O&#x2014;, and pharmaceutically acceptable salts thereof, their pharmaceutical formulations and use as HIV inhibitors. 

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Beerse, Belgium

Johannes Wilhelmus J Thuring