Synthelabo

Johannes Schoemaker

Samir Jegham

Thomas A Purcell

Jonathan Reid Frost

Alexander E Wick

Salomon Z Langer

Bernard Gaudilliere

Gerard Defosse

Regis Dupont

Jean Rousseau

Jean Bertin

Itzchak Angel

A compound which is a piperidine derivative of formula (I) ##STR1## in which R represents hydrogen, or unbranched or branched C.sub.1 -C.sub.6 alkyl group; and

Piperidine derivatives, their preparation and their application in

A compound which is a piperidine derivative of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom, a linear or branched (C.sub.1-6)alkyl group or a cyclo(C.sub.3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formula N--R.sub.3 in which R.sub.3 is a hydrogen atom, or a linear or branched (C.sub.1-8)alkyl, cyclo(C.sub.3-6)alkyl, cyclo(C.sub.3-6)alkylmethyl, (C.sub.1-4)alkoxy-(C.sub.1-4)alkyl, phenyl, pyridin-4-yl, pyridin-3-yl, pyridin-4-ylmethyl or pyridin-3-ylmethyl group and Z represents a hydrogen or fluorine atom and acid addition salts thereof with pharmaceutically acceptable acids, can be used for the treatment and prevention of disorders in which 5-HT receptors are involved.

Piperidine derivatives, their preparation and their therapeutic

Ifenprodil and its analogues are useful for the treatment of psychoses such as schizophrenia.

Method of treatment of psychotic disorders

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Gif-sur-Yvettte, France

Johannes Schoemaker