Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Other

Boehringer Ingelheim Gmbh

Johannes M Weisenberger

Helmut Pieper

Frank Himmelsbach

Volkhard Austel

Wolfgang Eisert

Thomas Muller

Thomas Mueller

Guenter Linz

Berthold Narr

Josef Nickl

Erich Muller

Gunter Linz

Brian Guth

Josef Roch

Armin Heckel

Walter Haarmann

Rainer Soyka

Elke Seewaldt-Becker

Gojko Muacevic

Josef Nickl, Deceased

Christopher Meade

F Himmelsbach

Rainer Zimmermann

Gerd Krueger

Thomas M Uller

G Unter Linz

Hans-Dieter Schubert

Volhard Austel

Austel: Volkhard

Austel Volkhard

Karl-Heinz Switek

Gunther Linz

The present invention relates to carboxylic acid derivatives of the general formula ##STR1## in which R.sub.a to R.sub.c, A, B, D, E and X.sub.1 to X.sub.3 are as defined in claim 1, their tautomers, their stereoisomers including their mixtures, and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases, which have useful pharmacological properties, preferably aggregation-inhibiting inhibiting actions, medicaments containing these compounds, their use and processes for their preparation.

Carboxylic acid derivatives, medicaments comprising these compounds,

Substituted phenylamindines, medicaments containing these compounds and

The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.

Biphenyl derivatives, pharmaceutical compositions containing these

The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.

Piperazine derivatives, medicaments comprising these compounds, their

The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.

Cyclic urea derivatives, pharmaceutical compositions containing these

The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.

The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.

Cyclic dericatives, pharmaceutical compositions containing these

5-Membered heterocyclic compounds, of which the following compounds are exemplary:

5-membered heterocycles, medicaments containing these compounds, their

Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are:

Piperazine derivatives, pharmaceutical compositions containing these

The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 production.

Arylsulphonamides, pharmaceutical compositions containing these

The invention relates to new labelled fibrinogen receptor antagonists which have an affinity for the receptor which is comparable to or greater than that of .sup.125 I-fibrinogen and whose binding is not disrupted by foreign proteins.

Labelled fibrinogen receptor antagonists, the use thereof and processes

Cyclic compounds and pharmaceutical compositions containing them

Growing community of inventors

Biberach, Germany

Johannes M Weisenberger