Beecham Group Plc

Beecham-wuelfing Gmbh & Co. Kg

Johannes Jukna

Charles D Nicholson

Harald Maschler

Rolf T Wilke

A compound of formula (I): ##STR1## or where appropriate a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 each independently represent a moiety of formula (a):

Xanthines

A method for the treatment and/or prophylaxis of disorders associated with neuronal degeneration resulting from ischaemic events, in mammals, such as humans, which comprises administering to the mammal in need of such treatment an effective amount of a 5-HT1.sub.A agonist.

Treatment of neuronal degeneration with 5HT1.sub.A agonists

A method for the treatment and/or prophylaxis of disorders associated with neuronal degeneration resulting from ischaemic events, in mammals, such as humans, which comprises administering to the mammal in need of such treatment an effective amount of a 5-HTl.sub.A agonist.

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Gronau, Germany

Johannes Jukna