Academisch Ziekenhuis Leiden

Octoplus Technologies B.v.

Johannes Jakobus Grote

Jan Wouter Drijfhout

Pieter Hiemstra

Maartje Johanna Nell

Guido Vincent Bloemberg

Marcel Jan Vonk

The invention relates to a peptidic compound with affinity to bacterial and fungal toxins, especially to lipopolysaccharide or lipoteichoic acid. The peptidic compound includes an amino acid sequence XKEFXRIVXRIKXFLRXLVX, wherein Xrepresents the N-terminal part: Xis K or E; Xis Q or E; Xis D or R; Xis N or E; Xrepresents the C-terminal part: an amino acid of the core sequence is optionally derivatized; the N-terminal part is acetylated, and/or the C-terminal part is amidated, and/or the sequence differs from the native amino acid sequence XKEFKRIVQRIKDFLRNLVX.

Peptide inhibitors of toxins derived from LL-37

The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.

Antimicrobial peptides derived from CAP18

Growing community of inventors

Zoeterwoude, Netherlands

Johannes Jakobus Grote