Immuno Aktiengesellschaft

Baxter Aktiengesellschaft

Stichting Sanquin Bloedvoorziening

Johannes J Voorberg

Koenraad Mertens

Jan Aart Van Mourik

Ellen Anne Maria Turenhout

Edward Norbert Van Den Brink

A polynucleotide, comprising a contiguous nucleotide sequence coding for a human antibody with factor VIII specificity, or complementary to a nucleotide sequence coding for a human antibody for factor VIII specificity, or capable of selectively hybridizing under stringent conditions to such nucleotide sequence. Such polynucleotide may be used as a probe or primer for detection of factor VIII inhibitors, or be used for producing a recombinant polypeptide. A polypeptide, comprising a contiguous amino acid sequence corresponding to or mimicking a fragment or derivative of a human antibody with factor VIII specificity capable of specific binding to factor VIII. An antibody, comprising a recombinant human antibody with factor VIII specificity or an anti-idiotypic antibody directed against a human antibody with factor VIII specificity. Pharmaceutical compositions which contain such polypeptide or antibody.

Method for diagnosis and treatment of haemophilia A patients with an inhibitor

Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.

Hybrid proteins with modified activity

Method and means for detecting and treating disorders in the blood

Growing community of inventors

Assendelft, Netherlands

Johannes J Voorberg