Universitätsklinikum Freiburg

Forschungszentrum Borstel

Klinikum Der Universitat Munchen

Albert-ludwigs-universitat Freiburg

Universitaetsklinikum Freiburg

Université De Caen Basse Normandie

Johannes Hübner

Otto Holst

Christian Theilacker

Zbigniew Kaczynski

Stefan Geiss-Liebisch

Karolina Kruszynska

Friederike Rossmann

Irina Sava

Agnieszka Beczala

Luis Felipe Romero Saavedra

Andrea Kropec Hübner

Axel Hartke

Andrea Kropec-Hübner

Felipe Romero

Andrea Kropec Huebner

Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against

Polypeptides derived fromand their use for vaccination and the generation of therapeutic antibodies

The present invention generally relates to the field of detecting and preventing infectious diseases caused byand/or. More specifically, the invention relates to anand/orantigen which comprises at least one unit having the following general formula: 

and/orantigen

The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.

Opsonic and protective monoclonal antibodies against gram-positive pathogens

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The present invention relates to a rhamno-polysaccharide antigen fromclonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.

The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.

Cell wall components of enterococci and uses thereof

Growing community of inventors

Freiburg, Germany

Johannes Hübner