Akzo N.v.

Akzo Noble N.v.

Johannes H Wieringa

Dirk Leysen

Ralf Plate

Gerardus Stephanus Ruigt

Frans A Van Der Vlugt

Franciscus H Van Bakel

Sjoerd F Van Aelst

Gerhardus J Heeres

Leonardus Petrus Delbressine

Sublingual or buccal pharmaceutical composition

The invention concerns a phenoxyphenyl compound having the formula ##STR1## wherein R is one or two halogen atoms; and

Phenoxyphenyl derivatives, compositions thereof and methods for their use

The invention relates to a piperazine derivative having the formula ##STR1## wherein each .phi. is a phenyl group which may independently be substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, CF.sub.3, and halogen, and Y is O or S, or a pharmaceutically acceptable salt thereof. The piperazine derivatives have sigma receptor affinity, and may be used for the treatment of psychosis.

Piperazine derivatives

The invention relates to a 3-quinuclidine derivative having the formula I ##STR1## wherein X is O or S, and R represents one to five substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower aralkyloxy, lower alkanoyloxy, halogen, NO.sub.2, CF.sub.3, CN, NR.sub.1 R.sub.2, and COR.sub.3, in which R.sub.1 and R.sub.2 are independently selected from hydrogen, lower alkyl, and lower alkanoyl, and R.sub.3 is selected from OH, lower alkyl, lower alkoxy, and NR.sub.4 R.sub.5, wherein R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl; or pharmaceutically acceptable salts thereof.

3-quinuclidine derivatives

The invention concerns a phenoxyphenyl derivative having the formula ##STR1## wherein R is one or two halogen atoms; and

Phenoxyphenyl derivatives, compositions and methods of use thereof

Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives having the general formula I: ##STR1## or a pharmaceutically acceptable salt or nitrogen oxide thereof, in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each represent independently hydrogen, hydroxy, halogen, cyano, alkyl, alkoxy or CF.sub.3 ;

Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives

This invention relates to dopamine uptake-inhibiting compounds of the general formula I: ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, NO.sub.2, OH, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, unsubstituted amino or C.sub.1 -C.sub.4 alkyl substituted amino;

Substituted aromatic compounds having an action on the central nervous

The invention relates to novel tetracyclic compounds with an anti-depressant action, without neuroleptic or sedative side effects, of the general formula I ##STR1## and also functional derivatives hereof, wherein: R.sup.1 represents one or two identical or different substituents denoting H, OH, halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; R.sup.2 represents one or two identical or different substituents having the same meaning as R.sup.1 ; R.sup.3 and R.sup.4 are two substituents which are in the cis configuration and of which one is H and the other is OH; R.sup.5 is H or C.sub.1 -C.sub.4 alkyl; X denotes O or S; n is 0 or 1.

Dibenzoxepinon and dibenzothiepino-pyridinol or - pyrrotol derivatives

The present invention relates to new tricyclic compounds of the formula: ##STR1## having valuable CNS and cardiovascular properties.

Biologically-active tricyclic amines

The present invention relates to new dibenzoxazonine, dibenz-oxazecine or dibenzo-oxaazacycloundecane derivatives and corresponding thia- and aza derivatives thereof, of the general formula I: ##STR1## or a pharmaceutically acceptable acid addition salt or nitrogen oxide thereof, in which

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Heesch, Netherlands

Johannes H Wieringa