Universitat Fur Bodenkultur Wien

Centre National De La Recherche Scientifique

Chanel Parfums Beaute

Buck Institute for Research on Aging

Université De Nice Sophia Antipolis

Guangzhou Institute of Biomedicine and Health

Evercyte Gmbh

Johannes Grillari

Regina Grillari

Matthias Hackl

Elisabeth Schraml

Sylvia Weilner

Klaus Fortschegger

Judith Campisi

Gordana Wozniak-Knopp

Duanqing Pei

Serge Holderith

Irina Berlin

Xavier Fernandez

Gerhard Stadlmayr

Gaëlle Gendronneau

Miguel Esteban

Anais Tromeur

Ting Zhou

Otto Kanzler

Abhijit Kale

Alexandre Casale

Stefan Vogt

Madhusudhan Reddy Bobbili

Ingo Lammermann

Florian Rueker

Florian Gruber

Marie-Sophie Narzt

Ingo LÄMMERMANN

Provided herein is a method of producing a protein comprising a target-specific extravesicular domain (TED) of an extracellular vesicle (EV) surface protein comprising modifying a polynucleotide comprising a nucleotide sequence encoding the extravesicular domain (ED) of an EV surface protein by a mutagenesis method within at least one modified region within the ED amino acid sequence with a length of 3-20 contiguous amino acids flanked by regions of the wild-type ED sequence at its N-terminus and C-terminus, to incorporate a target binding site within the ED, thereby producing a repertoire of polynucleotides encoding a variety of TEDs, each comprising a different target binding site, and selecting a TED specifically recognizing a predetermined target, and producing the protein comprising the selected TED.

Target-specific extracellular vesicles

The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected miRNAs is quantified in a sample from said subject.

Biomarkers for detecting senescent cells

The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected microRNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.

Compositions and methods for the diagnosis and treatment of bone fractures and disorders

An alcoholic extract of aerial parts ofsubsp.the method of production thereof, a cosmetic or dermatological composition containing it, as well as cosmetic and dermatological uses thereof, notably in the treatment of signs of skin ageing.

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The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro RNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.

Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.

Method of generating induced pluripotent stem cells and differentiated cells

Compositions of an inhibitor of a polynucleotide for use in treating or preventing bone disorders such as osteoporosis, osteopenia, bone fracture, bone cancer, as well as impaired bone homeostasis. Preferred compounds to be used in these medical interventions are antagonistic compounds, like nucleic acid molecules, directed against miR-31 and derivatives thereof. Also, methods for diagnosing and compositions for use in diagnosing bone disorders. Compounds to be employed in these diagnostic methods and uses include compounds such as miR-31.

Compositions for use in treating or diagnosing bone disorders and/or cardiovascular disorders

Panels of mammalian cell samples, kits and methods of use thereof. The panels comprise samples or sets of samples of immortalized primary cells, obtained from different tissues and organs of healthy and/or diseased donors. The cell panels are useful in assays for testing effects of drug candidates, e.g. for activity and toxicity.

Panels of immortalized mammalian cells and their use

The invention relates to methods for diagnosing bone disorders and/or cardiovascular disorders in a subject, by contacting a biological sample from the subject with (a) a nucleic acid molecule which hybridizes to miR-31 or its 5 or 3' isoforms or variants, or (b) an agent that binds to miR-31 or its 5&#x2032; or 3&#x2032; isoforms or variants; detecting and evaluating the hybridization signal of the nucleic acid molecule or agent with a polynucleotide or said miR-31 or its 5&#x2032; or 3&#x2032; isoforms or variants; and comparing the detected and evaluated hybridization or binding signal with that of a control sample, wherein a stronger hybridization signal or a stronger binding signal in the sample of the subject compared to that of the control sample is indicative for a risk of developing or having a bone disorder and/or cardiovascular disorder.

Methods for diagnosing bone or cardiovascular disorders

Growing community of inventors

Bisamberg, Austria

Johannes Grillari