Dsm IP Assets B.v.

Henkel Ag & Company, Kgaa

Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Dms IP Assets B.v.

Nederlandse Organisatie Voor Wetenschappelijk Onderzoek (nwo)

Nederlandse Organisatie Voor Wetenschappelijk Onderzoek

Johannes Gerardus De Vries

Laurent Lefort

Sandra Hinze

Werner Bonrath

Jonathan Alan Medlock

Matthias Beller

Johann Klein

Ligang Zhao

Andrea Gutacker

Ben De Lange

Andreas Hendrikus Maria De Vries

Rudy Francois Maria Jozef Parton

Richard Van Heck

Yuting Fan

Pim Puylaert

Quirinus B Broxterman

Jan-Erik Damke

Daniel Mink

Gerhard Steinbauer

Horst Beck

Anna Maria Cornelia Francisca Castelijns

Adrian Brandt

Alexander Kux

Pierre Louis Woestenborghs

Ulfried Felfer

Adrian Duracu

Martina Kotthaus

Johannes Augustinus Kroon

Michèle Catherine Christianne Janssen

Natascha Sereinig

Friso Bernard Jan Van Assema

David Hyett

Peter Johannes Dominicus Maas

Andreas H M De Vries

Arie De Rijke

Jeroen Antonius Franciscus Boogers

Barthel Engendahl

Michele Catherine Christianne Janssen

Hero Jan Heeres

Jeroen Boogers

Sergey Tin

Sebastian Schmidt

Teddy

Pim Huat Phua

Ignacio Vladimiro Melián Cabrera

Felix Geitner

Andrea Dellacqua

Ignacio Vladimiro MELIÁN Cabrera

David John Hyett

The present invention pertains to reactive (moisture curing) plasticizers; adhesives and sealants containing the plasticizers and methods of bonding and sealing substrates with adhesives and sealants containing the plasticizers.

Bio-based reactive plasticizer and adhesives and sealants containing them

The present invention relates to a selective reduction of specific aldehydes and ketones to their corresponding alcohols.

Selective reduction of aldehydes and ketones

The present invention relates to a selective reduction of esters to their corresponding alcohols.

Selective reduction of esters to alcohols

The invention relates to a process for the production of 5-formylvaleric acid and adipic acid or esters thereof from an isomeric mixture of pentenoic acid or esters thereof said mixture comprising at least 4-pentenoic acid or esters thereof, and further comprising 3-pentenoic acid and/or 2-pentenoic acid or esters thereof. The process allows for efficient production of two different intermediates for producing polyamide using a single process, with good selectivity, little waste, in an economically efficient fashion. The process is very suitable to use an isomeric pentenoic acid mixture obtained from valerolactone, and can be used to produce renewable polyamide intermediates using a single process.

Process for the preparation of formylvaleric acid and adipic acid

A process for producing furfural and levulinic acid from lignocellulose-comprising biomass is disclosed. The biomass is slurried using water and optionally an acid, subjected to hydrolysis, and then subjected to a solid/liquid separation to yield at least an aqueous fraction comprising C5 and C6 sugars and a solid fraction comprising cellulose and lignin. Furfural is obtained by adding an organic solvent to the aqueous fraction, heating at 120-220&#xb0; C. for a sufficient time to form furfural, cooling, and separating an organic phase comprising at least part of the furfural from an aqueous phase. Levulinic acid is obtained by suspending the solid fraction in water and optionally an acid, heating the suspension to 140-220&#xb0; C., and separating an aqueous fraction comprising the levulinic acid from a solid fraction.

Process for the production of furfural and levulinic acid from lignocellulosic biomass

The present invention relates to a method for preparing caprolactone, comprising converting 5-hydroxymethyl-2-furfuraldehyde by hydrogenation into at least one intermediate compound selected from the group of 2,5-tetrahydrofuran-dimethanol, 1,6-hexanediol and 1,2,6-hexanetriol, and preparing caprolactone from said intermediate compound. Further, the invention relates to a method for preparing 1,2,6-hexanetriol comprising preparing 5-hydroxymethyl-2-furfaldehyde from a renewable source, converting 5-hydroxymethyl-2-furfaldehyde into 2,5-tetrahydrofuran-dimethanol and converting 2,5-tetrahydrofuran-dimethanol into 1,2,6-hexanetriol. Further, the invention relates to a method for preparing 1,6-hexanediol from 1,2,6-hexanetriol, wherein 1,2,6-hexanetriol is subjected to a ring closure reaction, thereby forming (tetrahydro-2H-pyran-2-yl)methanol, and the (tetrahydro-2H-pyran-2-yl)methanol is hydrogenated, thereby forming 1,6-hexane diol.

Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran-dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde

The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: The process is particularly advantageous for the isomerization of substituted alkenes harboring a hydroxy group when the desired end product has a keto group, such as ricinoleic acid or ester thereof.

Process for the isomerisation of substituted alkenes

Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with Rbeing a branched Calkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10). 

Convergent synthesis of renin inhibitors and intermediates useful therein

The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140&#xb0; C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.

Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid

A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C-C-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.

Process for transition metal-catalyzed asymmetric hydrogenation of acrylic acid derivatives, and a novel catalyst system for asymmetric transition metal catalysis

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Maastricht, Netherlands

Johannes Gerardus De Vries