Alligator Bioscience Ab

Universiteit Utrecht

Umc Utrecht Holding B.v.

Johannes Antonius Gerardus Van Strijp

Cornelis Petrus Maria Van Kessel

Andreas Paul Peschel

Willem Jan Bastiaan Van Wamel

Suzan Huberdina Maria Rooijakkers

The invention relates to nucleic acid molecules encoding (poly)peptides having chemotaxis inhibiting (poly)peptides CHIPS activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having CHIPS activity and to the use of such recombinant (poly)peptides having CHIPS activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions and HIV. In addition, the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having CHIPS activity.

Nucleic acids encoding (poly) peptides having chips activity

The invention relates to the new use of Serum Amyloid P component (SAP) and/or endotoxin-binding fragments thereof for the preparation of a pharmaceutical composition for neutralizing lipopolysaccharide and particularly for the treatment of sepsis. The invention further relates to a diagnostic method for demonstrating the presence of endotoxin in blood or blood fractions, such as serum or plasma.

Pharmaceutical and diagnostic use of Serum Amyloid P component

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Odijk, Netherlands

Johannes Antonius Gerardus Van Strijp