Duphar International Research Bv

Johannes A Van Der Heyden

Cornelis G Kruse

Ineke Van Wijngaarden

Jan Hartog

Martinus T Tulp

Berend Olivier

Roelof Van Hes

Dirkje A Van Dalen-Van Der Aa

The invention relates to new compositions with pyschotropic activity which comprise a compound of formula 1 of the formula sheet as the active substance. The compounds of formula 1 are for the greater part new compounds. The invention therefore also relates to these new compounds and to the preparation thereof in a manner known for the synthesis of analogous compounds.

Bibyclic heteroacrylpiperazine derivatives having psychotropic activity,

The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties. The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.

Aryl-substituted (N-piperidinyl)methyl- and (N-piperidinyl) methylazoles

The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula ##STR1## wherein A is an unsaturated heterocyclic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent. The compounds have interesting pharmacological, notably antipsychotic properties.

Phenyl, Pyrrolidin-2-yl substituted pyrroles having antipsychotic

The invention relates to a group of new bicyclic heteroarylpiperazine derivatives of formula 1. It was found that these compounds have interesting psychotropic in particular anti-psychotic properties. The compounds can be prepared according to methods known for the synthesis of analogous compounds.

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Weesp, Netherlands

Johannes A Van Der Heyden