Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Ecole Nationale Superieure De Chimie De Paris

UniversitÉ De Paris

Universite De Versailles-st Quentin En Yvelines

UniversitÉ Paris Descartes

Johanne Seguin

Nathalie Mignet

Kathia Lemdani

Daniel Scherman

Vincent Boudy

Yoran Beldengrun

Camille Kurtz

Nicolas Lomenie

Vincent Pierre-Marie Boudy

Robert Malafosse

Armand Tiede Djiro

Claude Capron

Jean-Francois Emile

The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.

Immunomodulation after locoregional anti-tumoral treatment

The present invention relates to gelling compositions, which changes from liquid state to gel state in function of temperature comprising: at least a poloxamer or mixture of poloxamers; at least a gelling agent; and at least an anticancer agent. Said compositions are advantageously used for local administration of an anticancer agent. Said compositions are useful for size-reduction of a tumour before surgical removal of said tumour, for preventing tumour recurrence after surgical removal of a tumour, and/or treating small tumours. They are therefore useful for the treatment of cancer, preferably a cancer of a wall of the digestive system or a gynaecologic cancer. The present invention also relates to a method for preparing said gelling compositions.

Gelling compositions for treating malignant tumours and/or preventing tumour recurrence

The invention relates to a process for determining an infiltration profile of biological cells of interest in a biological object of interest from a digital histopathological image of biological tissues, a histological stain having previously been applied to the biological tissues,

Process for determining the infiltration of biological cells in a biological object of interest

Growing community of inventors

Kremlin-Bicêtre, France

Johanne Seguin