Wacker Chemie Ag

Johanna Koch

Amitabha Mitra

Markus Brunner

Marian Kujau

Megan Gutman

Megan Zarembski

Ryan Hollingsworth

A method of delivering an active compound includes providing a delivery device having a first portion. The first portion defines a first outer surface of the device. An active compound is provided in the first portion. The first outer surface exhibits a first tack after providing the active compound and a second tack of at least 25 percent the first tack after delivering the active compound to the first outer surface.

Method of delivering an active compound and delivery device for use in the same

A bacterial strain suitable for expressing recombinant proteins contains an open reading frame which codes for a recombinant protein, under control of a functional promoter. The bacterial strain contains an open reading frame which codes for a muted peptidologycan-associated lipoprotein (PAL protein), under control of a functional promoter, wherein the PAL protein is muted such that it contains no membrane anchor for the outer cell membrane of the bacterial strain. A plasmid codes for a recombinant protein. Fermentative production of recombinant protein is facilitated by using the bacterial strain, with increased product yields in the culture residue without leading to a substantial die-off of the bacterial cells.

Bacterial strain for releasing a recombinant protein in a fermentation method

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Munich, Germany

Johanna Koch