Centre National De La Recherche Scientifique

Universitè De Montpellier

Institut Curie

Université Montpellier 2 Sciences Et Techniques

Johann Soret

Jamal Tazi

Emile R Bisagni

David Grierson

Christian Rivalle

Chi Hung Nguyen

Philippe Jeanteur

The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromosome 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (Survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.

Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process

Growing community of inventors

Teyran, France

Johann Soret