Sanofi-A Ventis Deutschland Gmbh

Sanofi

Johann Gassenhuber

Evi Kostenis

Hartmut Strobel

Joachim Wink

Paulus Wohlfart

Jochen Kruip

Christian Viskov

Luigi Toti

Rolf Müller

Mark Broenstrup

Wulf Dirk Leuschner

Silke Wenzel

Kathrin Heermeier

Alexandra Ferrier

Natalie Karst

Alexandra Krog

Carsten Volz

Tina Binz

Claudia Koenig

Caudia Koenig

Rolf Mueller

The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

Gene cluster for biosynthesis of griselimycin and methylgriselimycin

The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.

Method of screening a modulator of endothelial NO synthase comprising the use of heme binding protein 1

The invention relates to a method for identifying a compound which stimulates or attenuates the activity of the G protein-coupled receptor mas-like 1.

Method for identifying agonists or antagonists of the G-protein coupled receptor mas-like 1

Embodiments of the present invention relate to methods for identifying compounds which modify the activity of the G protein-coupled receptor GPR45 like/GPR63, compositions useful for this method, and compounds identified by it.

Method for identifying agonists and antagonists of the GPR45-like/GPR63 receptor

The present invention relates to newly identified human EDG8 receptors, polynucleotides encoding this receptor, polypeptides encoded by such polynucleotides, the preparation and the use of such polynucleotides and polypeptides.

EDG8 receptor, its preparation and use

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Wiesbaden, Germany

Johann Gassenhuber