Gilead Sciences, Inc.

Johann Chan

Katie Ann Keaton

Dominika Pcion

James G Taylor

Dustin S Siegel

Darryl Kato

Adam James Schrier

Michael Sangi

Bruce Ross

Ruben Martinez

Nathan D Shapiro

Olga Viktorovna Lapina

Kapil Kumar Karki

Jonathan Clive Tripp

Henry G Morrison

Henry Morrison

Peter C Fung

Andrew W Waltman

Troy Evan Reynolds

Denise A Colby

Lina Chan

Donald Tang

Chris Levins

Adam Littke

Pamela Seng

Lawrence Yu

Dustin Bringley

Amy Cagulada

Justin Philip Vitale

Sudha Kondapally

Sudha Kondappally

Jonathan Tripp

The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Synthesis of an antiviral compound

Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.

Crystalline forms of an antiviral compound

The present disclosure relates to processes for preparing dronedarone or pharmaceutically acceptable salts thereof.

Process for preparing dronedarone and salts thereof

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Foster City, CA, United States of America

Johann Chan