Cor Therapeutics, Inc.

Other

Millennium Pharmaceuticals Limited

Johan Sundelin

Robert M Scarborough

Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor

Nucleic acids encoding the C140 receptor

Recombinant C140 receptor, its agonists and antagonists, and nucleic

Agonist and antagonist peptides of the C140 receptor

Method to determine ligands, agonist and antagonist of C140 receptor

The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

Recombinant C140 receptor

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Furulund, Sweden

Johan Sundelin