Pharmachemie B.v.

Johan Keegstra

Michael Imre Goller

Jan Arp

Erwin Van Achthoven

This invention provides a budesonide/formoterol dry powder inhaler () comprising:

Dry powder inhaler

Described herein is a dry powder inhaler which includes: a reservoir containing a dry powder formulation and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator for breaking up agglomerates of the dry powder medicament; a delivery passageway for directing an inhalation-induced air flow through a mouthpiece, the delivery passageway extending to the metered dose of medicament, and an inhalable &#x3b2;2-agonist having a particle size distribution of d10&#x3c;1 &#x3bc;m, d50=1-3 &#x3bc;m, d90=3.5-6 &#x3bc;m and NLT 99% 10 &#x3bc;m and a lactose carrier.

Inhalable medicaments

This invention provides a budesonide/formoterol dry powder inhaler () comprising: a reservoir () containing a dry powder medicament and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator (') for breaking up agglomerates of the dry powder medicament; a delivery passageway () for directing an inhalation-induced air flow through a mouthpiece (), the delivery passageway extending to the metered dose of medicament, wherein the medicament comprises micronised formoterol fumarate, micronised budesonide and a lactose carrier, the lactose carrier having a particle size distribution of d10=20-65 &#x3bc;m, d50=80-120 &#x3bc;m, d90=130-180 &#x3bc;m and &#x3c;10 um=&#x3c;10%.

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Haarlem, Netherlands

Johan Keegstra