Astrazeneca Ab

Albireo Ab

Astra Aktiebolag

Johan Gottfries

Maria Boije

Eva-Lotte Lindstedt-Alstermark

Anders Broo

Bengt Ohlsson

Michael Kossenjans

Maria Thorstensson

Li Lanna

Kristina A Nilsson

Tord Bertil Inghardt

Lanna Li

Kjell Andersson

Eva-Lotte Lindstedt Alstermark

Staffan Folestad

Goran Ostling

Tudor Oprea

Gunnar Zackrisson

Arne Torstensson

The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.

2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease

A computer based technique for the global investigation of property spaces is described. More particularly, a technique is described for the global investigation of chemical space, with reference to drugs, using a system comprised of molecules and descriptors that allows systematic mapping of the chemical space. The technique is used to generate a map of N-dimensional chemical space that allows one to examine, in a consistent manner with existing tools, the inner relationship between various molecules. The technique therefore allows one to investigate unexplored regions of the chemical space, avoiding redundancy, generating compounds with similar chemical information content, or to focus on subsets of the chemical space that are relevant to drug-like structures, without additional errors due to extrapolation.

Global method for mapping property spaces

Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.

3-aryl propionic acid derivatives and analogs

Method and an industrial process for determining dose-level

Growing community of inventors

Mölndal, Sweden

Johan Gottfries