Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Johan Fredrik Avallin

Klaus Gebauer

Gustav Jose Rodrigo

Nils Norrman

Ronnie Palmgren

Ola Lind

Andreas Torbjorn Lundin

Per Denker

Carina Andersson

A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: &#x2014;providing a feed from a cell culture () comprising said biomolecule to a magnetic separator () and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; &#x2014;separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; &#x2014;forwarding said magnetic beads as a slurry with an added buffer to an elution cell (); &#x2014;eluting the bound biomolecules in the elution cell.

Method and system for separating biomolecules

A method and a system and a container system for transferring separation resin from at least one first container (') to a second container (&#x2032;), wherein said first container is a deformable, single-use separation resin storage container, said method comprising the steps of:&#x2014;preparing (S1) the at least one first container by providing a deformable, single-use container comprising an outlet port (&#x2032;) with a predefined volume of separation resin in a storage solution;&#x2014;fluidizing (S3) the separation resin in the at least one first container to provide a resin slurry, said fluidizing being performed by mechanical interaction to the first container from an outside of the first container to provide a deformation of said first container;&#x2014;fluidically connecting (S5) the outlet port (&#x2032;) of the at least one first container to an inlet port () of the second container;&#x2014;transferring (S7) separation resin from the at least one first container to the second container by generating a pressure difference between an interior of the second container and an interior of the first container where the pressure is lower in the second container.

Method and system for transferring separation resin

A method and a system for transferring a slurry of a separation resin, from at least one first container to a second container, said method comprising the steps of:

An arrangement for a column comprising a stand provided with a platform adapted to receive a second end of a tubular housing and for supporting the arrangement on a floor, a first end unit removably connected to a first end of the tubular housing, an adaptor assembly movable within said tubular housing and an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit. A frame is connected to the first end unit, which frame and first end unit can be lifted and lowered in a substantially vertical direction, so that the tubular housing may be removed and substituted for another tubular housing with different dimensions in relation to the removed tubular housing when the frame and first end unit are lifted.

Arrangement for a column, a method for substituting a tubular housing in such an arrangement for a column and a method for conducting peptide and/or oligonucleotide synthesis in a column

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Uppsala, Sweden

Johan Fredrik Avallin