Gyros Patent Ab

Johan Engström

Mats Inganäs

Gunnar Thorsén

Cecilia Hellermark

A microfluidic device that comprises a microchannel structure in which there are one, two or more flow paths () all of which comprises a porous bed I () that is common for all of the flow paths and exposes an immobilized reactant R that is capable of interacting with a solute S that passes through the bed. The characteristics are that at least one of the flow paths comprises/comprise a second porous bed II () that is placed upstream of porous bed I () and is dummy with respect to interaction with solute S but capable of interacting with a substance DS that is present in a liquid aliquot together with solute S and is capable of disturbing the result of the interaction between solute S and said immobilized reactant R. There is also disclosed a method utilizing the device and variant of the device in which the immobilized R is replaced with a generic affinity ligand Land/or porous bed II exposes a generic ligand Lthat may be different from L.

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Uppsala, Sweden

Johan Engström