Photocure Asa

Photocure As

Balter, As.

Balter, Inc.

Johan E Moan

Qian Peng

Trond Warloe

Harald Steen

Karl E Gierskcky

Alf Bjorseth

Alf Bjørseth

Kristian Berg

Jo Klaveness

Aslak Godal

Nils Olav Nilsen

Jon Erik Braenden

Anders H&oslash;gset

Jakob J Stamnes

Knut Stamnes

Gennady Ryzhikov

Lu Zhao

Jahn M Nesland

Boerge Hamre

Robert Bissonnette

Karl E Giercksky

Kirsten Sandvik

Marina Biryulina

Kirsten Sandvig

Endre R Sommersten

Kristian Pagh Nielsen

Kristian P Nielsen

In an embodiment of the present disclosure, an optical method for determining morphological parameters and physiological properties of tissue is presented. The method includes using reflectance measurements from a tissue area for a plurality of wavelengths, using a bio-optical model, using radiative transfer modeling and using a non-linear inversion procedure. The method further includes systematically varying values of the morphological parameters and physiological properties of the tissue and simultaneously varying the inherent optical properties, which are linked to the morphological parameters and the physiological properties of the tissue, until the non-linear inversion procedure returns values for the morphological parameters and the physiological properties of the tissue such that an agreement between the reflectance measurements and reflectances computed by the radiative transfer model, based on the returned morphological parameters and the physiological properties of the tissue values and corresponding inherent optical properties values, reach a predetermined level of accuracy.

Optical method for determining morphological parameters and physiological properties of tissue

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) RN&#x2014;CHCOCH&#x2014;CHCO&#x2014;OR(wherein Rmay represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and Rrepresents a hydrogen atom or a group R, and both Rgroups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N&#x2014;CH2COCH2-CH2CO&#x2014;OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N&#x2014;CH2COCH2&#x2014;CH2CO&#x2014;OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

The present invention provides a compound of formula I;RN&#x2014;CHCOCH&#x2014;CHCO&#x2014;OR&#x2003;&#x2003;(I)wherein Rrepresents (a) an optionally substituted branched Calkyl group, comprising a straight chain Calkyl group, branched by substitution with one or more Calkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more &#x2014;O&#x2014;, NR&#x2014;, &#x2014;S&#x2014; or PR&#x2014; groups; R, each of which may be the same or different, represents a hydrogen atom or a group R, wherein Rrepresents (a) an optionally substituted branched Calkyl group, comprising a straight chain Calkyl group, branched by substitution with one or more Calkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more &#x2014;O&#x2014;, NR&#x2014;, &#x2014;S&#x2014; or PR&#x2014; groups; and Rrepresents a hydrogen or Calkyl group, and salts thereof for use in photochemotherapy or diagnosis. Pharmaceutical compositions comprising said compound, methods of diagnosis or photochemotherapy using said compound and related compounds and compositions, and products and kits comprising said compounds are also provided.

A skin preparation is described for protection against sunlight, containing UVA and UVB-absorbent agents, an ALA derivative and conventional supplementary substances, together with the use of the preparation.

Skin preparation

The invention provides pharmaceutical compositions comprising a protoporphyrin precursor photochemotherapeutic agent together with vascular stroma-localizing photosensitizers, optionally together with at least one surface penetration assisting agent and optionally with one or more chelating agents, and use of the same in treating disorders or abnormalities which are responsive to PDT, preferably exhibiting synergistically enhanced therapy, kits comprising same and methods of therapy and diagnosis.

Photochemotherapeutic compositions

The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.

Transfer of molecules into the cytosol of cells

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R N&mdash;CH COCH &mdash;CH CO&mdash;OR (wherein R may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R represents a hydrogen atom or a group R , and both R groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid as photosensitizing agents in

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Oslo, Norway

Johan E Moan