Gambro Lundia Ab

Pharmacia Biotech Ab

Other

Siemens Elema Ab

Valcuria Ab

Med Tech Invest Europe Ab

Johan Drott

Thomas Laurell

Johan Nilsson

Lars Wallman

Lennart Jönsson

Thomas Hertz

G&ouml;ran Cewers

Staffan Nilsson

Stefan Ulvenlund

Kristina Drott

Lars Rosengren

Johan Olson

Gerd Nilsson

Eddie Nils-Joel Nilsson

Kjell Lindstr&ouml;m

Catharina Salomonsson

The present invention relates to a pharmaceutical composition comprising an HDAC inhibitor, a pharmaceutically acceptable acid or salt thereof or a mixture of the acid and salt, provided both in a immediate release form and in an extended release form wherein 70-90 weight % of the HDAC inhibitor is provided in the immediate release form and the remainder of the HDAC inhibitor is provided in the extended release form. In further aspects the present invention relates to a kit comprising a number of doses of an HDAC inhibitor, a pharmaceutically acceptable acid or salt thereof or a mixture of the acid and salt thereof provided both in an immediate release form and in an extended release form. In still further aspects the present invention relates to an HDAC inhibitor, a pharmaceutically acceptable acid or salt thereof or a mixture of the acid and salt, provided in both an immediate release form and an extended release form, for use in a method of pretreating cancer, and a method of pretreating cancer using said HDAC inhibitor provided both in said immediate release form and said extended release form. Further aspects relate to combination treatment of cancer and to a dispenser for a blister pack.

Composition and method for pretreating cancer

The present invention describes a medical kitfor facilitation of changing a urinary catheter in a patient, wherein the medical kitcomprises a first component in the form of a containerand a second component being a clamping unitcomprising two opposite clamping portions, which containerand which clamping unitare adapted to be reassembled so that the clamping unitconstitutes an end unit of the containerand clamping unit, and which clamping unitallows for a catheterto be pulled through and between the clamping portionswhere the clamping portionshave a pressing effect on the catheterbut still allows for a sliding contact between the clamping portionsand the compressed catheter, allowing for gelatinization of a urethra from the inside out when a cathetercontaining lubricant/anaesthetic gel is pulled out from the patient and through and between the clamping portions, said catheterintended to be contained in the containerduring removal of the catheterand after usage for a hygienic procedure.

Medical kit for facilitation of changing a urinary catheter

A switching device for a fluid distribution set presenting a deformable portion having a first port, a second port, a third port and a fourth port, is disclosed. The switching device comprises an active portion adapted, in use, for clamping the deformable portion of the fluid distribution set, and a housing body defining a seat for receiving the deformable portion. The switching device can be operated according to first and second clamping positions, wherein the active portion is approached to a corresponding active surface of the housing body. A fluid control apparatus comprising the above switching device and the portion of the fluid distribution set is also described.

Switching device and apparatus for controlling flow of a fluid

A biological fluid device () comprises a pressure sensor (), which is arranged on the device. The pressure sensor comprises a compressible container, the compression of which is indicative of the pressure, and is capable of wireless communication.

Pressure sensing

Apparatus for measuring a property of a fluid is provided including a tube for retaining the fluid, the tube including a lateral access opening and a domed portion including a sealing surface on the outside wall of the tube surrounding the lateral access opening and a sensor sealingly disposed on the sealing surface surrounding the lateral access opening in the tube for direct contact with the fluid in the tube for sensing the property of the fluid in the tube.

Arrangement for measuring a property of a fluid present in a tube

The invention relates to a method for etching an opening, and more precisely, to etching in a silicon plate for creating a nozzle opening. According to the invention, one side of the silicon plate ( ) is protected by a protective layer ( ), and a recess ( ) is made in the protective layer. Etching is made anisotropically through the recess so as to create a cavity ( ) in the shape of a truncated pyramid of a predetermined depth in the silicon plate. The cavity is doped so as to create a doped layer ( ) at the predetermined depth. The etching is then continued until the bottom surface of the cavity has passed the doped layer. Subsequently, etching is performed from the other side, while a voltage is applied to the doped layer, so as to free the nozzle opening at the other side. The invention enables an accurate control of the surface area of the nozzle opening. Through this, the amount of discharged fluid and the directional precision can be controlled very accurately.

Method of etching an opening

A fluid flow meter has a semi-conducting substrate and a number of integral flexible tines orientated across an aperture in the substrate to deflect in the direction of the fluid flow by an amount dependent on that fluid flow. Piezo-resistive regions are included on the respective tines to provide them with electrical characteristics which vary dependent on the degree of deflection. A monitor, operably coupled to the regions of the tines, is provided to monitor the changes in their electrical characteristics and to calculate the flow therefrom.

Fluid flow meter

A sampling cell of flow-through type and use of such a sampling cell. The sampling cell is preferably manufactured by etching of silicon wafers. It is especially useful for continuous picovolume sampling in an analytical flow. The pressure pulse generator (,) generates pulses directly into a flow channel (,). The flow channel (,) is preferably formed by a first basin (,) in a first structure (,) and a second basin (,) in a second structure (,). In a first embodiment the pressure pulse generator (,) comprises at least one piezo-ceramic disc and/or devices acting by way of magnetostrictive, electrostatical or electromechanical forces and/or devices acting by way of thermal expansion. Method of directing samples from a flow-through sampling cell by establishing a difference in electrical potential between the liquid in the flow-through sampling cell and the object to which the samples are to be directed. Use of a flow-through sampling cell for coating of surfaces, especially for achieving biospecific surfaces, for extracting samples from a continuous liquid flow, for extracting a precise sample amount by collecting a defined number of samples or for injecting samples for electrophoresis, especially capillary electrophoresis, and for electrochromatography.

Flow-through sampling cell and use thereof

A silicon-based carrier matrix having a high ratio of surface area to volume is intended for use in integrated microanalysis systems. The carrier matrix comprises at least one layer of microporous silicon on a body of monocrystalline silicon. A method for producing the carrier matrix comprises electrochemical etching of a body of monocrystalline silicon, thereby to form at least one layer of microporous silicon on this body. The use of the carrier matrix for chemical sensors in integrated microanalysis systems, as well as in various sorts of chromatography, is also disclosed.

Growing community of inventors

Lund, Sweden

Johan Drott