Ligand Pharmaceuticals, Inc.

Johan Auwerx

Michael R Briggs

Stephen G Miller

Glenn E Croston

Bart Staels

Lluis Fajas

Regis Saladin

Piet De Vos

This invention relates to the isolation and cloning of the promoter and other control regions of human PPAR&#x3b3; gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of the PPAR&#x3b3; gene. These agents interact directly or indirectly with the promoter or other control regions of the PPAR&#x3b3; gene.

Human peroxisome proliferator activated receptor gamma (ppar&#x3b3;) gene regulatory sequences and uses therefor

This invention relates to the isolation and cloning of the promoter and other control regions of a human ob gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene. These agents interact directly or indirectly with the promoter or other control regions of the ob gene. A PPAR.gamma. agonist, BRL49653, has been identified to be useful in treating anorexia, cachexia, and other diseases characterized by insufficient food intake or body weight loss. Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.

Modulators of ob gene and screening methods therefor

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Millionfosse, France

Johan Auwerx