Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Johan Arthursson

Lotta Hedkvist

Key Hyckenberg

Petra Bangtsson

Eva Cecilia Olsson

Lena Nyholm

Karl Andersson

Pär Säfsten

Helen Bäckgren

Patrik Berglund

Francis Markey

Henrik Larsson

Annika Remaeus

Fredrik Edebratt

Ulrika Ohman

Patrick Berglund

A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.

Bioprocess system and method providing automated configuration detection

Method for determining the influence of least a first and a second experimental parameter on a liquid chromatography protocol for purifying one or more target molecules from a sample, comprising the steps: &#x2014;performing chromatography purifications of the sample at a plurality of different experimental conditions where at least the first and the second experimental parameter each are varied over a predetermined range, each purification being registered as a chromatogram by monitoring an output parameter indicative of the purification result during the purification; and&#x2014;displaying in a graphical user interface at least a subset of the registered chromatograms as chromatogram-miniatures in an evaluation diagram wherein the position of each displayed chromatogram-miniature is determined by the experimental parameters for the corresponding purification, thereby allowing a user to visually determine trends and the influence of the experimental parameters on the liquid chromatography protocol.

Method and system for determining the influence of experimental parameters on a liquid chromatography protocol

The present invention relates to a method of automated configuration in a bioprocess system () and to verify a process defined by a flow path representation. The method comprises the steps of: &#x2014;capturing one image of the bioprocess system () comprising tubing () for the fluid communication between units of the bioprocess system (); &#x2014;analyzing the captured image to identify the tubing () connecting units of the bioprocess system (); &#x2014;producing a processed representation from the captured image wherein at least a part of the tubing () is identified; and &#x2014;comparing the processed representation with the flow path representation to verify their functional concordance.

The present invention relates to a method for performing liquid chromatography purification of one or more target molecules from a sample comprising: providing an eluent flow having one or more target molecules, measuring an output parameter indicative of the content of the one or more target molecules in the eluent flow, storing output parameter data, and dividing the eluent flow into consecutive eluent fractions, dividing the output parameter data into corresponding data fractions, in each data fraction obtaining a value indicative of characteristic behavior of the measured output parameter, identifying trends in the measured output parameter based upon the obtained value in consecutive data fractions, and identifying peak(s) in the measured output parameter correlated to eluent fractions based upon the identified trends, whereby information of identified peak(s) and correlated eluent fraction(s) can be presented and purified sample(s) from the eluent may be collected.

Method and apparatus for performing liquid chromatography purification

A method and an apparatus for the development of a control process for an instrument are disclosed. The method comprises a first step of selecting one or more commands from a plurality of pre-defined commands in which at least one of the selected one or more commands being a purpose-linked command; and a second step of combining the selected one or more commands to produce the control process. The pre-defined commands have a control part for controlling the operation of the instrument and at least one of the pre-defined commands has a purpose part for controlling the purpose of the command. The apparatus for the development of a control process for an instrument comprises a first memory for storing a plurality of control parameters for individual ones of a plurality of commands, a display device for displaying information relating to the plurality of commands, a selection device for selecting ones of the plurality of commands and a processor for combining selected ones of the plurality of commands for producing the control process.

Method and apparatus for the development of a control process for an instrument

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Uppsala, Sweden

Johan Arthursson