The Ohio State University

The Cleveland Clinic Foundation

Jogikal M Jagadeesh

L David Tomei

Fred Cornhill

Michael Boninger

Raj Shekhar

Carlos R Castro-Pareja

Samuel S Bair

Amir M Abduljalil

Inching Chen

A system architecture is disclosed that facilitates rapid execution of 3D registration or alignment algorithms. A first image module (e.g., RAM) is included to store data corresponding to images to be registered. A processor coupled to the first storage module accesses the data and determined mutual histogram (MH) values which are then used to compute mutual information (MI) between the images. The processor accumulates the MH values in a second image module. The second storage module is accessible so that registered images can be displayed. The architecture is scalable facilitating distributed calculations to speed-up the registration process.

Architecture for real-time 3D image registration

An arbitrary function generator produces one or more waveforms for arbitrary applications wherein a general-purpose waveform production capability is customized to meet the demands of specific applications. The arbitrary waveform generator supports arbitrary scaling of waveforms in amplitude and in time. The arbitrary function generator is a standalone system that may be integrated into a MRI control system. In a preferred embodiment of the present invention, a software system comprising a delivery component, a configuration component, a scaling component, and a triggering component provide the features and functions of the present invention. The various software components communicate in accordance with a shared memory database in which data structures comprising waveform descriptions and tuning parameters are made available to the various software components.

Arbitrary function generator

A laser imaging system is disclosed which provides the versatility of wide field digital imaging with enhanced spatial resolution and light gathering efficiency. The system will scan targets of any size, dependent only upon the data retrieval and storage limitation of the computer support system, for forward light loss densitometry images as well as fluorescent and forward scatter images. The system is easily adaptable for rare event detection and tracking. The laser system will provide image capture of an entire target within 10 to 60 seconds and controls the scan of the laser beam in three-dimensional pattern and speed. The beam may be repositioned to any one of 16 million locations on a target within an accuracy of +/-0.5 um. Finally, the imaging system of the present invention utilizes a novel optical fiber based detector assembly having NA values of 0.58-0.95 and filters having less than 15% loss at emission wavelengths. Thus, the imaging system of the present invention can capture from 14% to 32% of total fluorescence emission.

Laser imaging system

A method and apparatus for measuring low-level laser-induced fluorescence are disclosed. A laser is used to produce a coherent beam of light which is sequentially passed through a beam expander, iris diaphram, focusing lens and three-dimensional scanner before being focused onto a rigidly mounted target. A computer is used to predeterminately control the pattern and the rate at which the scanner passes the beam of light over the target. The light transmitted onto the target induces fluorescent light in the target. The fluorescent light is sequentially gathered by a biased cut optical fiber member and directed into a photomultiplier tube where the intensity of the fluorescent light is measured. The intensity data is then digitized and recorded by the computer as a function of the coordinates of each preprogrammed point location of the beam impinging upon the target. This data is used to produce an image of all or a portion of the target on a visual monitor. In addition, the data can be recalled and used for further analysis of the target.

Growing community of inventors

Columbus, OH, United States of America

Jogikal M Jagadeesh