Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Joern Probst

Matthias Beyer

Ruth Houbertz-Krauss

Carsten Gellermann

Thomas Stichel

Miranda Rothenburger-Glaubitt

Doris Hanselmann

The present invention pertains to a process for producing three-dimensional, self-supporting and/or substrate-supported formed pieces or structures on surfaces by means of site-selective solidification of a liquid to pasty, organic or organically modified material within a bath consisting of this material by means of two- or multiphoton polymerization, whereby the material has at least one compound that has both an organic radical polymerizable via two-photon or multiphoton polymerization and a biocompatible, biodegradable or bioresorbable group, and/or wherein the bath material additionally contains groups or radicals, which are available for an inorganic crosslinking or which are already inorganically crosslinked, providing that both an organic radical polymerizable via two-photon or multiphoton polymerization and a biocompatible, biodegradable or bioresorbable group must be contained in the material. The formed pieces or surface structures according to the present invention are suitable as matrices for binding live cells, which can be multiplied after that or stimulated for the production of specific substances. They can be used, e.g., as an extracorporeal matrix or as an implant.

Method for generating biocompatible three-dimensional objects or surfaces by laser irradiation, such objects, the use thereof and starting materials for the method

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Kuernach, Germany

Joern Probst