Boehringer Ingelheim International Gmbh

Joern Merten

Svenja Renner

Carsten Reichel

Rolf Schmid

Juergen Schnaubelt

Guenter Linz

Werner Rall

Thomas Krueger

Heinz-Peter Schmitt

Bjoern Weyell

Michael Konrad

Thomas Fachinger

Emanuel Stehle

Carsten Puder

Markus Thumerer

Robert Schiffers

Bianca Werner

The invention relates to a process for preparing the corticosteroid ciclesonide, used for the treatment of respiratory complaints, in epimerically pure form of formula 1: 

Method for manufacturing of ciclesonide

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.

Process for the manufacture of an indolinone derivative

A process for preparing compounds of the formula (I) in which Rand Rare as defined in the description.

Preparation process

The present invention relates to specific indolinone derivatives, namely the compounds of formula, in which Rrepresents an hydrogen atom or a group, and Rand Reach represent an hydrogen atom or Rand Rtaken together represent a group, with the proviso that when Rrepresents an hydrogen atom Rand Rtaken together represent a group, and to a process for their manufacture. 

Indolinone derivatives and process for their manufacture

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Gau Algesheim, Germany

Joern Merten