Novo Nordisk A/s

Joern Drustrup

Henrik Bengtsson

Jonas Kildegaard Pedersen

Vera Pinto Glenting

A multi-use drug delivery device for extended use, wherein the multi-use drug delivery device comprising a multi-use main portion () and a single-use flow conducting device () adapted for conducting drug to the subcutaneous tissue of a subject, wherein the change from a connected configuration to an unconnected configuration of the main portion and the flow conducting device is through the intermediate configuration. The intermediate configuration comprises an equalizing channel defining an equalizing flow path () different from an unintended flow path (). The equalizing channel is adapted for equalizing the fluid pressure in a fluid communication volume () to the fluid pressure in the external environment, upon changing the configuration from the connected to the intermediate configuration and thereby expanding an internal volume, whereby an equalizing fluid flow along the equalizing flow path is larger than an unintended flow along the unintended flow path, whereby equalization of the fluid communication volume is provided with a reduced risk of introducing microorganisms from the flow channel () into the reservoir ().

Multi-use drug delivery device for drugs with less preservatives

An assembly includes a sealed drug reservoir unit, a subcutaneous flow conducting device in the form of a needle unit or an infusion set, and a flow communication unit. The flow communication unit includes a proximal hollow needle adapted to penetrate a needle-penetrable septum of the reservoir, a first flow-way inflow communication with the proximal needle and comprising a pressure-controlled valve, a second flow-way in flow communication with the first flow-way, an amount of preservative arranged to react with a substance received by the second flow-way, and distal flow communication structure adapted to provide flow communication between the second flow-way and the needle unit. The valve is controlled to open when the reservoir is pressurized, the preservative being provided to react with substances introduced to the second flow way via the needle unit.

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Farum, Denmark

Joern Drustrup