A/s Ferrosan

Schering Aktiengesellschaft

Scherling Ag

Joergen A Christensen

Mogens Engelstoft

Claus T Braestrup

Andreas Huth

Gunter Neef

Ralph Schmiechen

Ulrich Eder

Dieter Rahtz

Henning Schou

Mogens C Nielsen

Frank Waetjen

Joergen B Lassen

Birte K Skrumsager

A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## wherein: X is oxygen, sulphur or NR.sup.10, wherein R.sup.10 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkenyl, C.sub.3-7 -cycloalkyl or C.sub.3-7 -cycloalkenyl;

.beta.-carbolin-3-carboxylic acid derivatives useful for treating

New oxadiazolyl-imidazo-[1,4]benzodiazepine derivatives having benzodiazepine receptor activity have the formula ##STR1## R' is hydrogen, chlorine, fluorine or nitro in the 7- or 8-position, R.sup.1 is hydrogen or lower alkyl of up to 3 carbon atoms,

Oxadiazolyl-imidazo-[1,4]benzodiazepines and their use in treatment of

A method for assisting with appetite and weight control and reduction in obese human patients, which comprises the step of orally or rectally administering an appetite-suppressant compound selected from the group consisting of femoxetine and a pharmaceutically-acceptable salt thereof in an effective appetite-suppressant amount over a period of at least eight (8) weeks is disclosed. The appetite-suppresssant compound is preferably orally administered together with a pharmaceutically-acceptable carrier in a daily dosage of 100 to 1,000 mg in the form of a tablet containing about 100 to 300 mg of the appetite-suppressant compound, which is preferably a pharmaceutically-acceptable femoxetine acid addition salt, especially the hydrochloride.

Long-term weight reduction of obese patients using femoxetine

A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## has valuable pharmacological properties when administered to patients, e.g. humans as a drug, have been shown to possess interesting tranquilizing activity.

.beta.-Carbolin-3-carboxylic acid derivatives

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Virum, Denmark

Joergen A Christensen