Semba Biosciences, Inc.

Third Wave Technologies, Inc.

Sonoplot, Inc.

Joerg Werner Baier

Anil Rajaram Oroskar

Andrew Paul Wilke

Robert Charles Mierendorf

Anthony Charles Grabski

Victor I Lyamichev

Jeff G Hall

Bruce P Neri

Zbigniev Skrzypczynski

Sarah R Wayland

Bradley James Larson

Ned D Reimer

Herbert Edmund Paaren

Luis P Reynaldo

Thomas Paul Blandino

The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.

Valve module and methods for simulated moving bed chromatography

A device and method for the detection of the interaction between two or more objects is disclosed. The device utilizes electrical impedance spectra measured from a piezoelectric element attached to one such object. Comparison of such spectra along a range of traverse allows precise estimates of distance to be made. One useful application is the topographical mapping of a surface.

Device for detecting interaction with an object

Continuous isocratic affinity chromatography

The present invention provides compositions comprising oligonucleotides that have 3' end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3&#x2032; end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.

3' end tagged oligonucleotides

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Verona, WI, United States of America

Joerg Werner Baier