Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Susonity Commercial Gmbh

Joerg Von Hagen

Christian Jasper

William-Robert Pitner

Graham B I Scott

Marcel Breuning

Marcel Andre Breuning

Uwe Michelsen

Almut Rapp

Maria Wehsling

Michael Howard Rayner-Brandes

Tanino Scaramuzza

Michael Howard Rayner

Anke Simon

Nikolai Stankiewicz

Andrew Philip Salazar

Julia Bleifuss

Lisa Eckelhoefer

Alexander Paul Schiller

Peter A Leland

Jens Eichhorn

Anja Licht

Jochen Bastian Sieck

Jochen Bausch

Claudia Knack

Valerie Bicard Benhamou

Marcel André Breuning

The present invention relates to a process for manufacturing dry powder cell culture media. The preparation and usage of mixed particles generated by co-lyophilisation leads to cell culture media with improved solubility without changing the chemical composition.

Process for producing cell culture media

The present invention relates to mixtures of serine or threonine together with at least one further amino acid or amino acid derivative and with at least one calcium salt or its hydrate and methods including this mixture including specific mixtures of such components and a formulations consisting of the mixture and a solvent.

Method to increase cellular availability of calcium in skin cells and mixtures

The present invention relates to the purification of poloxamers to be used as cell culture media additives. Activated carbon can be used to remove hydrophobic high molecular weight components which reduce the efficacy of poloxamers as cell culture additives.

Method for purifying poloxamers

The present invention relates to cell culture media compositions comprising deep eutectic solvents and/or ionic liquids.

Deep eutectic solvents and/or ionic liquids in cell culture media

The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.

Cell culture media

The present invention relates to dry cell culture media comprising amino acid components of certain particle size. Some dry powder cell culture media show poor dissolving properties and result in turbid solutions when they are dissolved in aqueous solutions. Using amino acid components of certain particle sizes significantly reduces that problem.

The invention relates to a process for improving the solubility of dry cell culture media. Some dry powder cell culture media show poor dissolving properties and result in turbid solutions when they are dissolved in aqueous solutions. Using a stepwise procedure in which the amino acids present in the non-dissolving part are identified and added to a new batch in other particle sizes significantly reduces that problem.

Process for improving the solubility of cell culture media

The present invention relates to an a process for manufacturing dry powder cell culture media. The preparation and usage of mixed particles generated by co-lyophilisation leads to homogenously blended cell culture media.

The present invention relates to cell culture media comprising polymer embedded components. Some components show poor stability in dry powder cell culture media. Others are hygroscopic. Such components can be embedded into polymers to increase stability and reduce clumping.

The present invention relates to an apparatus and a process for manufacturing cell culture media. A specific cooling in combination with a certain type of mill lead to a production process that reduces decrease in the performance of the culture media. Preferably, the process is run continuously.

Process and apparatus for producing cell culture media

The present invention relates to the use of ionic liquids or of mixtures comprising at least one ionic liquid and at least one further solvent for the extraction of membrane proteins from biological samples, to methods for the extraction of membrane proteins, to a kit for the extraction of these proteins and to the use thereof.

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Pfungstadt, Germany

Joerg Von Hagen