Sandoz Ag

Joerg Salchenegger

Dominic De Souza

Martin Albert

Michael Oberhuber

Hubert Sturm

Helmut Schwab

Andreas Berger

Thorsten Wilhelm

Martin Langner

Ferdinand Zepeck

Daniel Luschnig

Hans-Peter Spitzenstaetter

Waander Riethorst

Peter Remler

Doris Osl

Dominic Desouza

The present invention relates to a process for the preparation of a chiral compound according to formula (V) wherein Ris preferably an alkyl residue preferably having from 1 to 6 carbon atoms, in particular to a process for the preparation of a chiral compound the crystalline chiral compounds as such, and their use for the preparation of an antifungal agent, in particular posaconazole. 

Process for the preparation of chiral hydrazides

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y&#x2014;NH; of formula (IIa) 0=C&#x2550;N&#x2014;Yand/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V). 

Process for the preparation of chiral triazolones

The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed. 

Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester

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Kundl/Tyrol, Austria

Joerg Salchenegger