Sanofi-a Ventis Deutschland Gmbh

Sanofi

Sanofi-aventis

Aventis Pharma S.a.

Joerg Rieke-Zapp

Heinz-Werner Kleemann

Gerrit Schubert

Guenter Billen

Luc Grondard

Stephane Mutti

Bao-Guo Huang

Joel Malpart

Reda Hanna

Yves Gouraud

Xiao-Dong Wu

Johannes Keil

Claus-Dieter Graf

Dieter Kadereit

Karl Schoenafinger

Elisabeth Defossa

Andreas W Herling

Thomas Klabunde

Alfons Enhsen

Maxime Lampilas

Karl-Ulrich Wendt

Hans-Joerg Burger

Erich Von Roedern

Michel Lavigne

Philippe Boffelli

Michel Delthil

Lahlou Nait-Bouda

Veronique Crocq-Stuerga

Karl-Urlich Wendt

The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.

Process for the preparation of enantiomeric forms of 2,3-diaminopropionic acid derivatives

The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoylphenyl)-acrylic ester derivatives as intermediates, to a process for optical resolution, and to intermediates of the process according to the invention.

Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives

The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II). 

Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives

The present invention relates to a novel method for the preparation of azetidine derivatives such as N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-ylmethylsulfonamide and the dihydrochloride thereof and N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.

Product, method and intermediates for the preparation of azetidine derivatives

A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board. In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.

The invention relates to a method for producing enantiomeris form of 2, 3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II). 

The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.

Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide

The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention particularly relates to compounds of formula I, in which the radicals have the given meanings described herein, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.

Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use

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Frankfurt-am-Main, Germany

Joerg Rieke-Zapp