Forschungsverbund Berlin E.v.

Max-delbruck-centrum Fur Molekulare Medizin

Freie Universitaet Berlin

Joerg Rademann

Walter Birchmeier

Christoph Arkona

Eric Nawrotzky

Ee Lin Wong

Klaus Hellmuth

Boo Geun Kim

Stefanie Grosskopf

A furazan-3-carboxylic acid derivative or pharmaceutically acceptable salt thereof for treatment of acute myeloid leukemia.

Furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer

The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formula (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated diseases, especially cancer and metastasis. The invention further concerns a method for treating a proliferative disease, a genetic disorder, an autoimmune disease, an angiogenic disorder or cancer in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of at least one compound of formula (I) and/or (II).

Shp-2 inhibitors and pharmaceutical compositions comprising them

Growing community of inventors

Berlin, Germany

Joerg Rademann