Hoffmann-la Roche Inc.

Genentech, Inc.

F. Hoffmann-la Roche Ag

Joerg Lill

Kurt Puentener

Rene Trussardi

René Trussardi

Simon Breitler

Filippo Sladojevich

Rene (deceased) Trussardi

The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5'hydroxy protecting group at the 5′-O-oligonucleotide terminus of the oligonucleotide by way of tangential flow filtration with an acidic buffer solution. The process requires less steps and allows a higher degree of automation.

Process for the purification of oligonucleotides

The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt of an oligonucleotide with a GalNAc cluster compound or with a salt thereof and a subsequent purification.

Process for GalNAc oligonucleotide conjugates

The invention comprises a new process for the preparation of GalNAc derivatives of the formula I 

Processes for the preparation of GalNAc acid derivatives

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Basel, Switzerland

Joerg Lill