Hoffmann-la Roche Inc.

Joerg Huwyler

Emmanuel Pinard

Georg Jaeschke

Juergen Wichmann

Roland Jakob-Roetne

Eric Vieira

Bernd Buettelmann

Alexander Alanine

Marie-Paule Heitz Neidhart

Anita Schnyder

Sonia Maria Poli

Ren&eacute; Wyler

Holger Fischer

Frederic Knoflach

The present invention provides a non-covalent coupling method for the preparation of sterically stabilized lipsomes which may be used for targeted drug delivery, e.g., pegylated liposomes. The method simplifies the attachment of targeting vectors to sterically stabilized liposomes. The present invention also provides a liposome composition comprising a compound of the formula and a compound of the formula Z-Y, wherein Z is any compound capable of binding to a cellular receptor, and X and Y are compounds which can interact with each other non-convalently, and wherein the substituents n, F1 and F2 are as provided in the specification.

Liposome compositions

The invention relates to carboxamide derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as mGluR1 enhancers in the treatment and prevention of neurological disorders and diseases, such as Alzheimer's disease and dementia.

Oxazoles as mGluR1 enhancers

The invention relates to compounds of formulaswherein Compounds of the present invention can be used for the treatment of diseases where Serum Amyloid P Component depletion has a beneficial effect, in particular in the treatment or prevention of central and systemic amyloidosis.

D-proline prodrugs

Prodrug acid esters of &lsqb;2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethansulfonyl&rsqb;phenol

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Burg, Switzerland

Joerg Huwyler