Roche Diagnostics Operations, Inc.

Roche Diabetes Care, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Joerg Dreibholz

Volker Unkrig

Carina Horn

Manfred Augstein

Wolfgang Schwoebel

Herbert Fink

Joachim Hoenes

Michael Marquant

Stefan Riebel

Christine Nortmeyer

Holger Kotzan

Volker Huellen

Sylvia Saecker

Rudolf Pachl

Bernd Hiller

Peter Seelig

Thomas Jaeck

Christian Freitag

Mihail-Onoriu Lungu

Daniela Pfiffi

Ingrid Keth

Elke Schmidtchen

Maria Dambach

Volker Hullen

Mihail Onoriu Lungu

Dieter Falk

Uwe Kass

Heinz Macho

Disclosed herein are methods of producing a test element for studying a body fluid sample. In the methods, a detection layer is covered with a polymeric spreading layer and applied to a support. The spreading layer can be produced by being sprayed onto the detection layer such that the spreading layer has a thickness of at most about 20 &#x3bc;m. Also disclosed are test elements produced by the methods, as well as tape cassettes incorporating such test elements.

Test elements and methods of producing the same for studying a body fluid sample

A method for manufacturing a test element for detecting at least one analyte in a body fluid, a test element for detecting at least one analyte in a body fluid, a method for detecting at least one analyte in a body fluid, a system for detecting at least one analyte in a body fluid and a method for manufacturing a test element for detecting at least one analyte in a body fluid are disclosed. The method for manufacturing a test element for detecting at least one analyte in a body fluid comprises the following steps: wherein at least one hydrophilic material is applied in a manner that at least one surface section of the channel surface is covered with the hydrophilic material, wherein the surface section is adjacent to the test chemical.

Method for manufacturing a test element for detecting an analyte in a body fluid

Methods of producing test elements for studying a body fluid sample

The invention concerns a test element analytical system for the analytical examination of a sample, especially a body fluid, comprising at least one test element with one or more measuring zones and contact areas located on the test element, in particular electrodes or conductor paths, the sample to be examined being brought into the measuring zone to carry out an analysis in order to determine a characteristic measured quantity for the analysis, and an evaluation instrument with a test element holder for positioning the test element in a measuring position and a measuring device for measuring the characteristic change, the test element holder containing contact elements with contact areas which enable an electrical contact between the contact areas of the test element and the contact areas of the test element holder, characterized in that one of these contact areas is provided with an electrically conductive hard material surface.

Test element analysis system with contact surfaces coated with hard material

A test tape cassette is disclosed that includes a cassette housing and an analytical test tape. The test tape includes a plurality of analytical test elements, a spreading fabric for applying a body fluid, and an underlying reagent layer for detecting an analyte in the body fluid. The cassette housing has an application tip that has a guide path extending longitudinally to the test tape in an arched-shape and is uncurved at right angles thereto for supporting the test tape in a kink-free manner. The guide path has an apex area with a central opening that delimits a measuring window for an optical measurement on the test elements.

Test tape cassette and analytical test tape therefor

A method for producing an analytical consumable is proposed. The analytical consumable comprises at least one carrier and at least one analytical aid connected to the carrier. At least one optically sensitive material is applied to the carrier, said material being designed to carry out at least one optically detectable alteration in the event of action of an electromagnetic radiation. In at least one coding step, at least one function information item about the analytical consumable is introduced into the optically sensitive material by means of electromagnetic radiation. The function information item is designed to enable at least one analytical instrument to use the analytical consumable correctly.

Method for producing an analytical consumable

The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.

On-board control for analytical elements

Systems and method for optically imaging objects and in particular optical patterns or codes onto a detection device by a pinhole aperture are described. According to an embodiment of the invention these systems have optical attenuation elements between the illumination devices and the object which substantially compensate the system-inherent imaging detects caused by the pinhole aperture and in particular the system-inherent peripheral decrease in brightness of an image of the object formed by a pinhole aperture on the detection device. According to an embodiment of the invention, the optical attenuation elements change the illumination intensity of the object in such a manner that the central areas of the object are illuminated at a lower light intensity than its peripheral areas. As a result of the subsequent imaging of the object by a pinhole aperture, the central areas of the object are imaged onto the detection device at a higher light intensity than the peripheral areas of the object. The superimposition of the two effects enables the imaging system according to the invention to achieve a substantially uniform system-inherent brightness distribution on the detection device.

System and method for optically imaging objects on a detection device by a pinhole aperture

A method and a corresponding system for error checking an electrochemical sensor having at least two electrodes and a liquid measuring medium applied thereto are disclosed. The method discloses determining a first admittance between a first set of electrodes of the sensor; determining a second admittance between a second set of electrodes of the sensor; determining a value using the first admittance and the second admittance; and displaying an error message if the value is out of a predetermined tolerance.

Method and system for error checking an electrochemical sensor

A method and a corresponding system for error checking an electrochemical sensor having at least two electrodes and a liquid measuring medium applied thereto are disclosed. The method involves determining a first admittance between a first set of electrodes of the sensor; determining a second admittance between a second set of electrodes of the sensor; determining a value using the first admittance and the second admittance; and displaying an error message if the value is out of a predetermined tolerance.

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Altrip, Germany

Joerg Dreibholz