Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Université Paris Diderot-Paris 7

Inserm (institut National De La Sante Et De La Recherche Medicale)

L'assistance Publique - Hopitaux De Paris

Inserm

Joëlle Benessiano

Alain Tedgui

Ziad Mallat

Philippe Gabriel Steg

Jean-Marie Freyssinet

A method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, includes:&#x2014;determining the sPLA2 activity of the patient as a first risk marker&#x2014;determining at least the value of a second risk marker chosen among CRP level, IgM IC of apo B 100 level or IgM MDA-LDL level&#x2014;determining the ratio (odds ratio) between the value of the sPLA2 activity and the value of the second risk marker and comparing it to a predetermined odds ratio, the odds ratio compared to the predetermined odds ratio being indicative of an increased risk of mortality or of a cardiac and/or vascular event. A new micro method adaptation for automated fluorimetric measurement of serum secretory phospholipase A2 is also disclosed.

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Paris, France

Joëlle Benessiano