Adir Et Compagnie

Adir Et Cie

Joel Vian

Jean-Louis Peglion

Mark Millan

Jean C Poignant

Jean L Peglion

Bertrand Goument

Valerie Audinot

Jean-Charles Schwartz

Aimee Dessinges

Pierre Sokoloff

Jean-Christophe P Harmange

Jean-Paul Vilaine

Nicole Villeneuve

Jean-Pierre Bidouard

Philip Janiak

Val Erie Audinot

New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers,

Heterocyclic tertiary amines

New compounds of formula: ##STR1## wherein A-B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.

Tetracyclic piperidine and 1,4-oxazine compounds

New compounds of formula: ##STR1## wherein: A-B, n and Y are as defined in the description, their optical isomers and physiologically tolerable salts thereof with appropriate acids. The products of the invention may be used as medicaments.

5,6,7,8-tetrahydronaphtho[2,3-b]furan and indano[5,6-b]furan amine

New compounds of formula: ##STR1## wherein A--B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.

Tetracyclic 1,4-oxazine compounds

The compounds are 3-[ (benzocycloalkyl)alkyl amino alkyl] -1,3,4,5-te trahydro 2H- 3-benzazepin-2 ones useful in cardiovascular field. A compound disclosed is (R,S)-7,8-dimethoxy-3-{3-{N-[(4,5-dimethoxybenzocyclobut-1-yl) methyl]-N-methyl amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one.

(Benzocycloalkyl) alkylamines

The compounds are N-substituted N'-(benzisoxazolyl or benzisothiazolyl) piperazines useful as sedative, anxiolytic, anti-aggressive and analgesic agents and for the treatment of schizophrenia and depression. A compound disclosed is (R,S)-3-{1-[(benzocyclobutan-1-yl)methyl]piperazin-4-yl}-6-fluoro-1,2-benz isoxazole.

Benzisoxazole and benzisothiazole compounds

Compounds of general formula I, ##STR1## in which: R.sub.1 denotes a hydrogen atom or, with the proviso, however, that the amino radical is at the 7-position, a linear or branched alkyl radical containing 1 to 4 carbon atoms,

2,4,5,6,7,8-Hexahydronaphtho[2,3-b]furan useful as an intermediate

Compounds of the general formula I ##STR1## in which R.sub.1 and R.sub.2, which may be identical or different, each denote a hydrogen atom, a benzyl radical, a cyclohexylmethyl radical or a linear or branched alkyl radical containing from 1 to 10 carbon atoms, optionally substituted with a hydroxy radical, with a carboxy radical or with an alkoxy radical having 1 to 5 carbon atoms, with an alkoxycarbonyl radical having 2 to 6 carbon atoms, with an alkylphenyl radical having 7 to 16 carbon atoms or with a 2-alkylthienyl radical having 5 to 14 carbon atoms,

Certain dihydrobenzofuran butanoic and pentanoic acid derivatives

Pharmacologically active amino-5,6,7,8-tetrahydronaphtho [2,3-B] furan

Compound of general formula I ##STR1## in which R.sub.1 and R.sub.2, which may be identical or different, each denote a hydrogen atom, a benzyl radical, a cyclohexylmethyl radical or a linear or branched alkyl radical containing from 1 to 10 carbon atoms, optionally substituted with a hydroxy radical, with a carboxy radical or with an alkoxy radical having 1 to 5 carbon atoms, with an alkoxycarbonyl radical having 2 to 6 carbon atoms, with an alkylphenyl radical having 7 to 16 carbon atoms or with a 2-alkylthienyl radical having 5 to 14 carbon atoms,

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Chaville, France

Joel Vian