Burroughs Wellcome Co.

Glaxo Wellcome Inc.

Joel Van Tuttle

Thomas A Krenitsky

Susan Mary Daluge

George Walter Koszalka

John W Selway

Charlene L Burns

Martin J Slater

Lowrie M Beacham, Iii

Sylvia M Tisdale

Wayne H Miller

A method for treating HIV infections comprising administering a composition whose active ingredient is 2',3'-dideoxy-3'-fluoro-5'-chlorouridine.

Method of treating HIV infections with

A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides:

Method for the treatment of protoza infections with 2.sup.1

2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2', 3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of scrotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.

Treatment of adenovical infections with 3'-fluoro-5-halo uracil compounds

This invention relates to certain 2'-fluoro nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the production of the compounds according to the invention.

Therapeutic nucleosides

2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.

Growing community of inventors

Durham, NC, United States of America

Joel Van Tuttle