Pfizer Corporation

Pfizer Products Inc.

Joel Thomas Arcari

Michael Luzzio

Matthew Arnold Marx

Samit Kumar Bhattacharya

Donn G Wishka

Susan D La Greca

Jinshan Michael Chen

Jun Xiao

Kendra Louise Nelson

Matthew David Wessel

James Alfred Southers, Jr

Arthur Douglas Brosius

Gonghua Pan

Susan Deborah La Greca

Jinshan Chen

The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula and R, R, R, A, K, M, L, L, X, Y, Y, Q, salt thereof, wherein R, R, R, A, K, L, L, W, X, Z, Z, Y, Y, Z, Z, M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Pyrimidine derivatives for the treatment of abnormal cell growth

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

Pyrrolopyrimidine derivatives

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Groton, CT, United States of America

Joel Thomas Arcari