University of Pennsylvania

Other

Joel Rosenbloom

Yoshinobu Higuchi

Masahiro Iwamoto

Maurizio Pacifici

This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as 'C-11 gene') which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as 'C-11 protein') has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.

Cell calcification suppressing proteins, and genes of the proteins

This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as &ldquo;C-11 gene&rdquo;) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as &ldquo;C-11 protein&rdquo;) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.

Growing community of inventors

Philadelphia, PA, United States of America

Joel Rosenbloom