The University of British Columbia

Sunnybrook Research Institute

Ryerson University

Joel Ramjist

Konrad Walus

John Madden

Jerry Ku

Christopher Pasarikovski

Yuta Dobashi

Victor Yang

Described herein are systems, devices and methods that enable dynamic modification of the physicochemical properties of a hydrogel during its in vivo formation and delivery by a catheter. In some example embodiments, an extended endoluminal hydrogel delivery device is employed for delivering a hydrogel within a given body cavity, such as within the lumen of a blood vessel. In some example embodiments, a hydrogel precursor, as a non-viscous liquid, is injected through an intravascular catheter and crosslinking of the hydrogel precursor is initiated within a distal region of the catheter. The crosslinking process is controlled, by a control means associated with a distal region of the catheter, to control or modify one or more properties of the hydrogel. The properties may be controlled such that a hydrogel is suitable to embolize the specific target or deliver drugs or other materials beneficial to the site.

Hydrogel co-injection and real-time opto-electromagnetic modification device for tunable in-vivo delivery

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TORONTO, Canada

Joel Ramjist