Merck + Co., Inc.

Alza Corporation

Joel R Zingerman

Rey T Chern

Jeffrey N Clark

Paul K Wilkinson

Marlene D Drag

John R Cardinal

Controlled release of hydrophobic bioactive substances in vivo over an extended time period and without &ldquo;bursts&rdquo; of drug release is achieved using a liquid polymeric composition including a polymer such as poly(lactide-co-glycolide) copolymer in a mixture of hydrophilic and lipophilic solvents.

Liquid polymeric compositions for controlled release of bioactive substances

Sulfurpentafluorophenylpyrazoles of formula I are highly potent against flea and tick infestations in animals. The compounds may be formulated to provide products with long duration of action and low potential for inducing vomition and other adverse reactions in treated animals.

Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic

There is disclosed an insert for the orifice of a ruminal bolus. The insert fits within the exit orifice of the ruminal bolus such that the medicated paste being discharged passes through the insert creating a back pressure within the paste compartment of the bolus which improves the performance of the bolus. The insert also prevents foreign objects from becoming lodged in the orifice. The insert consists of a grid-like series of openings with insert members extending into the orifice for a significant portion of the total length. Integral with the insert is a flange which secures the insert within the orifice and prevents it from being removed from the orifice or from being driven into the orifice.

Orifice insert for a ruminal bolus

This invention relates to an improved controlled release bolus device wherein the improvement comprises attaching at the orifice a screen or insert which prevents blockage of the orifice by exogeneous materials, but does not vary the flow of medicament from the device.

Growing community of inventors

Westfield, NJ, United States of America

Joel R Zingerman