Other

Safety Diagnostice, Inc.

Safety Diagnostics, Inc.

Aronowitz, Jack, L.

Joel R Mitchen

Sidney T Smith

John M Weiss

Jack L Aronowitz

Irwin Weitman

Jack L Aronowtiz

Carl W Jones

The present invention relates to noninvasive transdermal systems comprised of a noninvasive transdermal patch and a reflectometer. The noninvasive transdermal patches are comprised of a wet chemistry component and a dry chemistry component. The wet chemistry component is a liquid transfer medium in the form of a gel layer for the extraction and liquid bridge transfer of the analyte of interest from the biological fluid within or beneath the skin to the dry chemistry component. The dry chemistry component is a reagent system for interacting with the analyte of interest (glucose) to generate a color change. The reflectometers include a modulated light source for emitting light to illuminate a target surface which possesses a certain color and shade of color for detection by an optical detector. The output signal is processed for determining a corresponding quantity or quality measurement.

Noninvasive transdermal systems for detecting an analyte in a biological fluid and methods

The present invention relates to noninvasive transdermal systems and methods for analyte extraction from a biological fluid within or beneath the skin, such as interstitial fluid, and detection of the analyte. More particularly, the present invention relates to noninvasive transdermal patches comprised of a wet chemistry component and a dry chemistry component. The wet chemistry component is a liquid transfer medium in the form of a gel layer for the extraction and liquid bridge transfer of the analyte of interest from the biological fluid within or beneath the skin to the dry chemistry component. The dry chemistry component is a super sensitive or conditioned membrane carrying a reagent system for interacting with the analyte of interest to generate an indicator molecule, e.g., color change, to confirm detection of the analyte, and methods of use thereof. The indicator molecule may be visually observed by the individual user or observed by an electronic interpretation component, such as a reflectance spectrophotometer for detection. A particular analyte of interest which may be detected accurately, reliably and quantitatively in accordance with the present invention is glucose. The noninvasive transdermal systems of the present invention are low in-cost and suitable for convenient use by non-medical personnel.

Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods

A relatively painless method of safely collecting and testing blood which comprises piercing a patient's skin and collecting any blood and other fluids on a test disk moistened with a vehicle liquid. Several embodiments of a novel disposable apparatus having a reservoir of vehicle liquid for use in practicing the method also are described.

Blood collection and testing means

A relatively painless method of safely collecting and testing blood comprises piercing a patient's skin, bathing the pierced area with a vehicle liquid and collecting a sample of the vehicle liquid and any blood on a test disk in the apparatus. A novel disposable apparatus for practicing the method also is described.

Blood collection and testing method

A non-invasive method for collecting tissue fluids from a human or an animal which comprises pretreating the external surface of an area of the skin of the human or the animal with a solution to clean off dead cells, forming a liquid coating over the skin, forming a superficial contusion on that area of the skin without nicking or piercing the skin, sealing that area of the skin and then collecting tissue fluid from the area of the contusion with the assistance of vacuum. The tissue fluid collected may be used for diagnostic purposes. A device for practicing the method is also disclosed.

Growing community of inventors

Pompano Beach, FL, United States of America

Joel R Mitchen