Centre National De La Recherche Scientifique

Universitè De Montpellier

Université De Nice Sophia Antipolis

Universite Montpellier 2-Sciences Et Technique

Joël Nargeot

Michel Lazdunski

Pierre Escoubas

Bernard Lebleu

Fabrice Marger

Christophe Piot

Stéphanie Barrere

Prisca Boisguerin

Emmanuel Bourinet

The invention relates to fragments of the Death-Domain Associated protein (DAXX protein) and of the Fas-Associated Death Domain protein (FADD protein) that inhibit cell apoptosis, in particular cell apoptosis mediated by the Fas receptor. The invention also relates to derivatives of said anti-apoptotic fragments, conjugates comprising said fragments, pharmaceutical compositions comprising said fragments, and to the medical applications of said fragments, derivatives, conjugates, and pharmaceutical compositions thereof in the treatment or prevention of diseases and conditions associated with apoptosis.

Inhibitors of apoptosis and uses thereof

A peptide with the following sequence YCQKFLWTCDSERPCCEGLVCRLWCKIN (SEQ ID NO 1) or a derivative thereof, and nucleic acids coding for the peptide having the sequence (SEQ ID NO 1). Also the use of this peptide as an antagonist and/or reverse agonist of T-type calcium channels. A use of the peptide for preparing a drug, in particular an analgesic one.

Identification of novel antagonist toxins of T-type calcium channel for analgesic purposes

Growing community of inventors

Montpellier, France

Joël Nargeot